When I surf websites like dribbble, I feel this terrible temptation of approving myself to the dominant mass, but than I think: what about branding? Branding is all about distinctiveness, and distinctiveness in UI has a key role in influencing brand awareness, particularly when talking about websites. When I look at web apps like mint.com, posterous or even Facebook, I see great examples of designs with a brand behind, with a great ability of being recognizable.
What I ask myself, then, is if a less nice-looking and more distinctive UI design is what I should focus on. I know, I know what's in your mind now: nice look and distinctiveness can simply live together, this is obviously true. But the real question is: what to sacrifice? What to focus on?