Hello HN, we recently published FUSTA, a piece of software that tries to alleviate the pain of reading & writing huge FASTA files, which is something that we meet quite frequently.
FUSTA leverages FUSE to expose a FASTA file as a hierarchy of sequence files, either raw or in the FASTA format, and let you either read them as individual files, or rename/delete/edit/add some of them.
Thought it may be of interest to the biologists/bioinformaticians here; we use it on macOS, Linux & FreeBSD, feedback & suggestions welcome!